Managing thousands of SKUs, handling dynamic pricing, and scaling globally? It’s a lot, and you’re not alone. Research shows that 80% of B2B companies struggle with inefficiencies in their eCommerce systems, costing them time, money, and—let’s face it—peace of mind. These challenges become insurmountable without the right B2B eCommerce platforms.

For manufacturers, wholesalers, and distributors, choosing between Adobe Commerce and Shopify Plus could define your ability to manage relationships, scale operations, meet customer expectations, and sell products—all while staying ahead of your competitors. From real-time inventory syncing to custom catalog management, this article will break down how these platforms compare—and which one aligns with your growth goals.

We know the challenges you face. So, today’s article isn’t about broad comparisons. It’s tailored for B2B brands like you—leaders navigating the complexities of sprawling catalogs and overcoming inefficiencies tied to managing thousands of SKUs.

Whether you’re looking at Adobe Commerce for its flexibility or Shopify Plus for its simplicity, we’ll dig into the strategies that align with your goals.

Let’s break down the complexity, get to the heart of what works, and help you find the platform that scales with your success.

The B2B eCommerce Challenge: Managing Complexity

You don’t run a B2B business without grappling with complexity—it’s baked into the nature of wholesale, manufacturing, and distribution. Managing 10,000+ SKUs sounds straightforward until you factor in data consistency & product information management, customization and personalization, pricing & competitive intelligence. 

Add to that the challenges in keeping your product data accurate and organized, tailoring the experience for each customer, and using smart pricing to stay ahead of competitors.

That’s a living, breathing challenge.

And then there’s the bulk orders. These are intricate processes requiring tiered pricing, multi-approvals, and split shipments. If even one step falters—like a delay in supplier delivery or a pricing mismatch—entire workflows come to a halt. 

The stakes? Losing customer trust, missing revenue opportunities, and overburdening teams with avoidable firefighting.

What Complexity Really Looks Like

Running a successful eCommerce doesn’t end with having an online store. The real challenge starts after that by having to balance the intricate dynamics that affect customer trust and business efficiency. 

Here’s a closer look at the challenges wholesalers, manufacturers, and distributors face:

1. Dynamic, Per-Client Pricing

In B2B, every client is unique—and so are their pricing needs. Whether it’s volume-based discounts, region-specific adjustments, or tailored contracts, managing this complexity manually is a recipe for errors.

  • The Struggle: Without a system that dynamically handles pricing, businesses rely on spreadsheets and manual updates, which leads to mistakes, miscommunications, and unhappy clients.
  • The Solution: Adobe Commerce offers granular pricing tools that sync with CRM and ERP systems, automating price adjustments for every client contract.

Example: A distributor using Adobe Commerce can eliminate pricing errors by integrating its pricing rules with a live inventory feed, ensuring clients always see their negotiated rates.

2. Real-Time Global Scaling

Expanding across borders means navigating a web of region-specific regulations, from tax structures to language localization. In eCommerce, even a minor inconsistency—like showing an incorrect VAT or shipping timeline—can break trust and lead to lost deals.

  • The Struggle: Managing global operations with disconnected systems makes staying compliant and localizing experiences a constant uphill battle.
  • The Solution: With features like multi-language, multi-currency, and real-time compliance tools, Adobe Commerce ensures global scaling doesn’t sacrifice accuracy.

Example: A B2B wholesaler who is expanding into three new markets can use Magento’s automated VAT adjustments and localized content delivery to increase international revenue.

3. Automating Stock and Inventory Alignment

Managing complex supply chains in eCommerce often comes down to maintaining accurate, synchronized stock levels. For SKU-heavy businesses, small misalignments can result in costly stockouts or overstocking.

  • The Struggle: When inventory data isn’t automated, delays in supplier updates or unexpected demand surges ripple through the entire supply chain, causing delivery hiccups and frustrated clients.
  • The Solution: Adobe Commerce’s real-time inventory syncing and supplier integration tools keep stock levels accurate, even during fluctuating demand.

Example: A machinery distributor can reduce inventory mismatches, thanks to automated lead time updates and synchronized supplier data.

Beyond the Obvious

The real challenge isn’t managing complexity—it’s turning it into a competitive advantage. Businesses that thrive are the ones orchestrating complications with precision.

  • Regulatory Intelligence Built In: Adobe Commerce helps you comply with GDPR and PCI DSS, while proactively updating systems with region-specific tax adjustments and audit trails.
  • Seamless Supplier Orchestration: Through integrations with platforms like Epicor or SAP, you can automate contract updates, sync lead times, and dynamically adjust inventory based on supplier performance—all without manual intervention.
  • Localization at Scale: Multi-language, multi-currency, and tax-adaptive features help B2B companies offer personalized shopping experiences globally while maintaining efficiency locally.

Adobe Commerce Vs. Shopify Plus ROI: The Best B2B Platform for Managing SKUs

Your business isn’t one-size-fits-all, so why should your B2B eCommerce platform be? For manufacturers, distributors, and wholesalers, the choice between Adobe Commerce and Shopify Plus is about finding a platform that scales with your operations while addressing unique B2B challenges.

Yes, features are important, but here’s how the two platforms stack up, broken down into the areas that matter most for businesses like yours.

What? The ChallengeAdobe CommerceShopify Plus
Catalog Management: Handling Complexity at ScaleManaging thousands of SKUs is about organizing them with attributes, categories, and dynamic fields that reflect your business’s complexity. The challenge is handling intricate hierarchies, bulk updates, and region-specific variations without errors or delays. Purpose-built for complexity, Adobe Commerce supports dynamic attributes, bulk uploads, and advanced catalog management. For example, a manufacturer with 20,000 SKUs can easily update product specs across multiple regions with a few clicks, keeping everything aligned.While Shopify excels with its user-friendly interface, it struggles to handle vast product hierarchies efficiently. Adding complex attributes often requires custom development or third-party apps, increasing operational overhead.
ERP and CRM Integration: Bridging Data Across SystemsYour B2B eCommerce platforms can’t work alone—they need to sync with ERP and CRM systems like SAP, Microsoft Dynamics, or Salesforce to keep orders, inventory, and customer data consistent. Seamless integration becomes increasingly complex for businesses, especially when scaling across global markets.Offers advanced APIs and native support for ERP and CRM integrations. A distributor using SAP can easily sync inventory updates and order tracking with Adobe Commerce in real time, reducing errors and manual effort.Relies heavily on app-based integrations. While this works for smaller businesses, scaling operations with large ERP systems often requires middleware solutions, adding complexity and cost.
Multi-Channel Scalability: Growing Without LimitsB2B growth is multi-channel. Expanding globally, managing multiple storefronts, or integrating with marketplaces demands flexibility. Platforms must handle multi-language, multi-currency, and multi-store setups seamlessly, without relying on cumbersome workarounds.Excels here, offering multi-store capabilities and native support for multiple languages and currencies. A wholesaler selling across Europe and Asia can manage localized storefronts with ease, ensuring a consistent customer experience.Designed for simplicity, Shopify handles single-store setups well but relies on third-party apps to enable multi-channel operations, which can create inconsistencies.
Personalization and AI: Crafting Tailored ExperiencesB2B customers now expect more than just transactions—they demand personalized recommendations, dynamic pricing, and tailored experiences. Delivering this level of personalization at scale requires robust AI capabilities seamlessly integrated into your platform.Leverages Adobe Sensei AI for personalized product recommendations and dynamic pricing based on customer behavior. For instance, a wholesaler can offer custom discounts to repeat buyers based on past orders.While it supports basic personalization through third-party apps, it lacks the native AI capabilities needed for advanced use cases like dynamic pricing.
Regulatory Compliance and Traceability: Staying Ahead of StandardsIndustries like pharmaceuticals and chemicals operate under strict regulations requiring detailed traceability and compliance reporting. Your platform must provide tools to simplify audits and meet standards, especially when scaling globally.Shines in regulated industries with built-in traceability features that ensure compliance with standards like GDPR or FDA regulations.Limited in compliance features, often relying on third-party apps to fill the gaps—adding layers of complexity for regulated B2B businesses.
Total Cost of Ownership: Balancing Costs and ScalabilityOften businesses equate scaling with upfront investments. However, it’s about balancing long-term scalability, maintenance, and performance optimization. This is where businesses find it difficult to weigh initial costs against lasting value to ensure sustainable growth.While it comes with higher upfront costs, its flexibility and scalability deliver significant ROI over time. For example, businesses managing rapid growth often save on custom development costs thanks to its built-in features.Lower upfront costs make it attractive for smaller businesses, but scaling often leads to rising subscription and app fees, which can erode cost advantages as operations grow.
Performance and HostingOffers a high level of flexibility and scalability. Its cloud hosting, powered by its microservices architecture, is built for businesses handling massive SKU counts and seasonal traffic surges. With features like full-page caching and advanced performance tools, it ensures your platform stays fast and reliable, no matter the load.Offers a high-level level of flexibility and scalability. Its cloud hosting, powered by its microservices architecture, is built for businesses handling massive SKU counts and seasonal traffic surges. With features like full-page caching and advanced performance tools, it ensures your platform stays fast and reliable, no matter the load.Takes a more straightforward approach with its fully hosted infrastructure. It’s great if you’re looking for a hands-off hosting experience, but the trade-off is limited customization. You may also need to rely heavily on third-party apps to optimize performance, which can get costly and complicated. 
Checkout ExperienceB2B buyers want a user experience that’s as intuitive and engaging as B2C platforms. From navigating vast catalogs to accessing personalized recommendations, UX plays a critical role in customer satisfaction and retention. The challenge is delivering intuitive navigation, mobile-first designs, and personalized dashboards for every user.The checkout is as flexible as your business needs it to be. Multi-step approvals, account-based payments, and bulk order processing can all be customized to match your workflows. Need to split invoices or offer specific payment terms to certain clients? Adobe Commerce handles that seamlessly. While excellent for B2C simplicity, it starts to fall short when it comes to these more complex requirements. It offers a smooth and streamlined experience, but for advanced B2B needs—like tiered pricing or custom checkout workflows—you’re often left relying on third-party apps or workarounds. 
User Experience (UX)For B2B businesses, performance is non-negotiable. From handling bulk orders to supporting high SKU counts and global traffic, your platform’s hosting capabilities directly impact your operations. You need to ensure fast load times, zero downtime, and the ability to scale dynamically during traffic surges—all without skyrocketing hosting costs.Designed to cater to the complexity and personalization demands of B2B eCommerce. Thanks to AI-driven personalization powered by Adobe Sensei, your buyers can enjoy tailored product recommendations and dynamic content, creating an experience that feels crafted just for them. The platform also supports fully customizable storefronts and mobile-first designs, ensuring your brand stands out and your buyers can navigate with ease.Polished and easy to use but often feels generic for B2B operations. Personalization requires third-party apps, and dashboards lack the tailored features that businesses with intricate buyer journeys need.

Real-World Scenarios: Platform Capabilities in Action

To make the right choice between Adobe Commerce and Shopify Plus you have to see them in action. Here’s how each platform performs in key B2B scenarios, from managing vast catalogs to scaling internationally.

Scenario 1: Managing 20,000 SKUs Across Global Markets

For manufacturers managing sprawling product catalogs, the complexity comes from scale and specificity. Each SKU might have different pricing across regions, distinct compliance requirements, and unique attributes for local markets. The stakes? A pricing error or regulatory misstep could erode trust or stall operations.

How Adobe Commerce Handles It

Adobe Commerce’s dynamic catalog management excels here.

  • Regional Pricing: Configure pricing rules based on geography, currency, or customer tiers—all without disrupting other catalog areas.
    Example: A machinery manufacturer operating in North America and Europe can use Adobe Commerce to automate region-specific VAT and product pricing. Updates that once took weeks now happen in hours.
  • Bulk B2B Inventory Management: Adobe Commerce’s bulk upload tools and advanced APIs streamline inventory updates for thousands of SKUs. Integration with ERP systems ensures every change is synced across channels.

Shopify Plus’s Approach

While Shopify Plus can handle large catalogs, it often requires custom apps to manage regional pricing and tax compliance. For businesses with fewer regions or simpler compliance needs, Shopify’s ease of use is an advantage, but it may not scale as effectively for global complexity.

Scenario 2: Speed-to-Market for a New Product Launch

Distributors often need to launch products quickly—whether it’s to meet seasonal demand or respond to market shifts. The challenge is deploying the storefront and enabling key features fast enough to capitalize on opportunities.

How Shopify Plus Handles It

Shopify Plus is built for speed and simplicity.

  • Rapid Deployment: The platform’s intuitive setup and pre-built templates allow distributors to get storefronts up and running in days rather than weeks.
    Example: A beauty distributor launching a holiday product line can use Shopify Plus to create a fully operational store within five days, leveraging its app ecosystem for quick add-ons like B2B inventory management and promotional tools.
  • App Ecosystem: Shopify’s extensive app store allows businesses to quickly integrate third-party solutions like email marketing or payment gateways without complex configurations.

Adobe Commerce’s Approach

While Adobe Commerce offers unmatched customization, its robust configuration process may slow down initial deployment. However, for businesses needing highly customized storefronts or workflows, the investment in time pays off in long-term flexibility.

Scenario 3: ERP Integration and Custom Catalogs for B2B Wholesalers

For wholesalers, every client is unique. Custom catalogs, personalized pricing, and seamless integration with ERP systems are non-negotiable. The challenge lies in keeping these systems in sync while scaling operations.

How Adobe Commerce Handles It

Adobe Commerce is designed for complex integrations and personalization.

  • ERP Sync: Its advanced APIs integrate seamlessly with systems like SAP and Microsoft Dynamics, ensuring that inventory, pricing, and order data flow without manual intervention.
    Example: A food wholesaler using SAP can integrate it with Adobe Commerce to enable real-time updates for order processing and stock levels, reducing errors significantly.
  • Custom Client Portals: Adobe Commerce supports tailored portals for each client, enabling personalized catalogs and contract-based pricing. Wholesale customers see only what’s relevant to them, improving order accuracy and satisfaction.

Shopify Plus’s Approach

Shopify Plus relies on app-based integrations for ERP systems, which may work well for simpler setups. However, for businesses managing intricate workflows or high transaction volumes, these apps often require additional middleware, adding to operational complexity.

Scenario 4: Scaling from Regional to International

Mid-sized businesses expanding into global markets face challenges like localizing stores, managing multiple currencies, and complying with regional regulations. A platform’s ability to handle this transition can determine how smoothly growth happens.

How Adobe Commerce Handles It

Adobe Commerce’s multi-channel scalability makes it ideal for global expansion.

  • Multi-Storefront Management: Businesses can launch separate storefronts for different regions, each with tailored content, pricing, and tax settings—all managed from a single backend.
  • Localization Features: Multi-language, multi-currency, and built-in compliance tools (like GDPR support) ensure a seamless experience for international customers.

Shopify Plus’s Approach

Shopify Plus simplifies single-store setups and offers apps for multi-language and multi-currency support. For smaller-scale international expansion, it’s a user-friendly option. However, businesses managing multiple regions or storefronts often encounter limitations that require custom solutions, increasing costs over time.

What These Scenarios Reveal

Adobe Commerce shines in handling complexity, customization, and scale, making it ideal for businesses with intricate workflows and global ambitions. Shopify Plus stands out for simplicity and speed, serving businesses that need quick deployment and lower complexity.

Each platform excels in its niche. The key is aligning their strengths with your business’s specific needs—whether that’s managing vast inventories, integrating ERP systems, or expanding into international markets.

The Big Picture: Beyond Features to Strategy

Choosing between Adobe Commerce and Shopify Plus is about anticipating your business’s trajectory and understanding the trade-offs that come with each platform. Here’s what you need to consider when looking beyond the features.

1. Long-Term Scalability: Thinking Ahead

When you’re planning for growth, the ability to scale seamlessly is critical. An open-source platform like Adobe Commerce often outshines SaaS solutions like Shopify Plus in handling long-term operational complexity.

Why is Adobe Commerce Preferred?

Adobe Commerce allows businesses to customize every layer of their platform, from catalog structures to integration workflows. For example, a global distributor managing high-SKU catalogs can create bespoke tools for regional tax compliance and bulk B2B inventory management. Shopify Plus, while scalable, depends heavily on third-party apps for similar functionality, which can add hidden costs over time.

What is its USP?  

With open-source, you control the code, making it easier to scale as your operations grow. Whether you’re expanding into new markets or adding complex pricing rules, Adobe Commerce evolves with your needs. Shopify’s app ecosystem provides flexibility, but dependency on external tools may limit scalability for businesses with intricate workflows.

What’s the Result?

If you anticipate rapid growth or highly customized requirements, Adobe Commerce offers the flexibility to grow without outgrowing your platform.

2. Hidden Costs: What Lies Beneath

The sticker price of B2B eCommerce platforms is just the beginning. True cost emerges when you factor in development, app dependencies, and maintenance.

Why is Shopify Plus Preferred?

Shopify Plus’s lower upfront costs can be appealing, but reliance on apps for everything from multi-store setups to advanced integrations adds to your monthly bill. Adobe Commerce, on the other hand, involves higher development costs initially but eliminates ongoing app expenses for built-in capabilities.

What is its USP? 

Think of it as a choice between renting and owning. Shopify Plus is like renting a furnished apartment: quick to move in but limited in customization, and every additional feature increases the rent. Adobe Commerce is like owning a home: more upfront investment, but you have the freedom to renovate and adapt as needed—without recurring add-on fees.

What’s The Result? 

When weighing costs, consider not just what you pay today but what you’ll pay tomorrow as your business evolves.

3. Benefits of Headless Commerce for B2B: Preparing for the Future

Headless commerce is transforming eCommerce by decoupling the front-end user experience from back-end operations. Both platforms support headless solutions, but their approaches differ.

Why is Adobe Commerce Preferred?

Adobe Commerce’s API-first architecture is built to support headless commerce natively, offering seamless integration with progressive web apps (PWAs) for fast, customizable user experiences. Shopify Plus supports headless setups too, but it requires additional middleware, which can complicate implementations.

What is its USP? 

Headless commerce for B2B is ideal for prioritizing personalized user experiences, lightning-fast load times, and multi-device compatibility. For instance, a B2B company offering custom portals to clients could leverage a headless setup to deliver tailored, real-time experiences without altering the back-end infrastructure.

What’s the Result?

If creating differentiated customer experiences is part of your long-term strategy, Adobe Commerce’s native headless capabilities give you an edge.

4. Decision-Making Framework: What’s Right for You?

When complexity meets choice, having a clear decision-making framework can simplify the process. Here’s a tailored decision tree to help B2B businesses weigh their options:

Choosing between Adobe Commerce and Shopify Plus.

Why Strategic Thinking Matters

Every business is unique, and so is its growth path. Adobe Commerce offers depth and flexibility for companies managing complexity, while Shopify Plus delivers simplicity and speed for those prioritizing ease of use. 

The key is aligning your platform with your long-term goals—because eCommerce is more than transactions. It’s your growth engine.

Helping You Choose the Right Path

Choosing between Adobe Commerce and Shopify Plus.

Choosing between Adobe Commerce and Shopify Plus is a strategic move that impacts how your business grows and scales. From managing SKUs and pricing to integrating with ERP systems and scaling globally, the right platform aligns with your unique challenges and opportunities.

For businesses handling complexity, Adobe Commerce stands out with its depth and flexibility. If speed and simplicity are your priorities, Shopify Plus offers a streamlined solution. Either way, the key is understanding how these platforms support your long-term goals—and that’s where HumCommerce comes in.

Your Growth, Our Expertise

We’ve guided countless B2B businesses through eCommerce transformations, helping them scale efficiently while solving complex operational puzzles. Whether you’re navigating platform decisions or looking to optimize your existing setup, we’re here to help.

Let’s Build Your Future Together

Your eCommerce platform should do more than keep up—it should drive your growth. Let us help you identify the perfect fit for your business, so you can focus on what matters most: delivering exceptional experiences to your customers.

Ready to take your B2B operations to the next level?

Schedule a free consultation today and let’s create a strategy that works for you.


Frequently Asked Questions

1. How do Adobe Commerce and Shopify Plus support multi-location warehouses?

Think about the challenge of managing inventory across multiple warehouses. Every location has its own stock levels, shipping zones, and timelines. If your system isn’t up to the task, you’ll quickly face stock mismatches and delivery delays.

With Adobe Commerce, you’re covered. Its native tools let you allocate inventory to specific warehouses, sync stock in real-time, and even automate fulfillment logic. Say you’ve got a distributor handling regional orders—Adobe Commerce makes sure shipments always come from the closest warehouse, saving you time and money.

Shopify Plus? It gets the basics right. Multi-location support is there, but for anything advanced—like dynamic inventory allocation—you’ll likely need third-party apps. It’s a workable solution, but it adds complexity where you don’t want it.

2. Which platform handles regulatory compliance for pharma or chemicals better?

If you’re in a regulated industry like pharmaceuticals or chemicals, compliance is paramount. From detailed traceability to audit-ready reporting, you need a platform that simplifies the process.

Adobe Commerce is built for this. With tools to meet standards like FDA, GDPR, and PCI DSS, it tracks your products from supplier to customer, making audits and regulatory checks a breeze.

Shopify Plus can handle basic compliance, but advanced needs often require third-party integrations. It’s not a bad option, but piecing together tools adds cost and complexity—things you don’t need when regulations are already complicated enough.

3. Can Shopify Plus manage B2B pricing tiers dynamically?

B2B pricing is tricky. Every client might have a unique deal—bulk discounts for one, region-specific adjustments for another. Managing all that manually? It’s a disaster waiting to happen.

With Adobe Commerce, you don’t have to worry. It automates everything: tiered pricing, per-client contracts, regional adjustments—you name it. Plus, its ERP and eCommerce integration means pricing updates sync everywhere automatically, so your team always has accurate data.

Shopify Plus can do tiered pricing too, but for anything more complex, you’ll be relying on apps. And while apps are fine for smaller operations, they can quickly become a bottleneck when you’re scaling.

4. How does Adobe Commerce’s AI stack up for B2B personalization?

B2B buyers are impressed with functionality but they really want experiences tailored to them. Personalized recommendations, dynamic pricing, and promotions that feel like they were made just for them.

Adobe Commerce, powered by Adobe Sensei, takes personalization to the next level. Imagine a wholesaler who automatically suggests complementary products based on past orders or sends promotions tailored to a client’s buying patterns. That’s what Adobe Sensei does—it makes personalization seamless and scalable.

With Shopify Plus, personalization exists, but it’s through third-party apps. While those apps work, they don’t provide the depth or integration that Adobe Commerce offers. It’s personalization, but not as precise or effortless.